Scamp1^tm1Sud
Targeted Allele Detail

Summary

• Symbol: Scamp1^tm1Sud
• Name: secretory carrier membrane protein 1; targeted mutation 1, Thomas C Sudhof
• MGI ID: MGI:2445741
• Gene: Scamp1 Location: Chr13:94337818-94422339 bp, - strand Genetic Position: Chr13, 49.22 cM, cytoband D1
• Alliance: Scamp1^tm1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58332
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: Exons 3 and 4 were replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded amino acids 46 through 144. No protein was detected in homozygous mutant mice by Western blot analysis. (J:58332)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Scamp1 Mutation: 23 strains or lines available

References

• Original: J:58332 Fernandez-Chacon R, et al., Analysis of SCAMP1 function in secretory vesicle exocytosis by means of gene targeting in mice. J Biol Chem. 1999 Nov 12;274(46):32551-4
• All: 1 reference(s)