Ighm^tm2.1Che
Targeted Allele Detail

Summary

• Symbol: Ighm^tm2.1Che
• Name: immunoglobulin heavy constant mu; targeted mutation 2.1, Jianzhu Chen
• MGI ID: MGI:2445756
• Synonyms: delta mu-s^-
• Gene: Ighm Location: Chr12:113382446-113386350 bp, - strand Genetic Position: Chr12, 62.1 cM, cytoband F1-2
• Alliance: Ighm^tm2.1Che page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59960
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The floxed neo cassette that replaced the endogenous splice donor site was excised from Igh-6^tm2Che via in vivo cre mediated recombination. No transcript was detected by Northern blot analysis of homozygous mutant mice. (J:59960)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ighm Mutation: 56 strains or lines available

References

• Original: J:59960 Kuzin II, et al., Normal isotype switching in B cells lacking the I mu exon splice donor site: evidence for multiple I mu-like germline transcripts. J Immunol. 2000 Feb 1;164(3):1451-7
• All: 1 reference(s)