Tg(Prnp-tTA)F959Sbp
Transgene Detail

Summary

• Symbol: Tg(Prnp-tTA)F959Sbp
• Name: transgene insertion F959, Stanley B Prusiner
• MGI ID: MGI:2445786
• Synonyms: Tg(Prnp-tTA/F959), Tg(Prnp-tTA)FV
• Transgene: Tg(Prnp-tTA)F959Sbp Location: unknown
• Alliance: Tg(Prnp-tTA)F959Sbp page

Transgene origin

• Strain of Origin: FVB.129S7(B6)-Prnp^tm1Cwe/J

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: A tet transactivator gene under the control of a mouse Prnp promoter was used for the transgene. The mouse Prnp promoter targets transgene expression to the brain. High levels of transgene expression was observed in the cortex and hippocampus, and lower levels were observed in thalamic, hypothalamic, and brainstem regions via mRNA in situ hybridization. (J:50359)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

This transgene was originally microinjected into Prnp^tm1Cwe oocytes. Founder F973 exhibits the highest level of transgene expression, followed by founders F959 and F966.

References

• Original: J:50359 Tremblay P, et al., Doxycycline control of prion protein transgene expression modulates prion disease in mice. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12580-5
• All: 12 reference(s)