Tg(KRT14-cre)1Amc
Transgene Detail

Summary

• Symbol: Tg(KRT14-cre)1Amc
• Name: transgene insertion 1, Andrew P McMahon
• MGI ID: MGI:2445832
• Synonyms: K14 cre, K14-cre, K14cre, K14Cre, Krt14^Cre, Krt14Cre
• Transgene: Tg(KRT14-cre)1Amc Location: unknown
• Alliance: Tg(KRT14-cre)1Amc page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(KRT14-cre)1Amc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  KRT14 (3861)

  Krt14

  (MGI:96688)

• Mutation details: The transgene is composed of a cre recombinase gene under the control of a human keratin 14 promoter. The human KRT14 promoter directs transgene expression in hair and skin. The transgene also contains a human growth hormone sequence and polyadenylation signal. When crossed to a transgenic reporter line, beta-galactosidase activity was detected in the oral ectoderm at 11.75 dpc, and at 14.5 dpc activity is detected in the skin and throughout the dental epithelium. (J:65294, J:243633)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	KRT14 (human) Summary of all recombinase alleles driven by KRT14. Comparative matrix view of recombinase activities Alliance human KRT14 gene page

Disease models

Expression

In Mice Carrying this Mutation:

223 assay results 30 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(KRT14-cre)1Amc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

This allele is representative of 2 founders (#199 and #200) exhibiting the highest level of transgene expression.

Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.

References

• Original: J:65294 Dassule HR, et al., Sonic hedgehog regulates growth and morphogenesis of the tooth. Development. 2000 Nov;127(22):4775-85
• All: 392 reference(s)