Tg(CNTN2-CNTN1)1Gnn
Transgene Detail

Summary

• Symbol: Tg(CNTN2-CNTN1)1Gnn
• Name: transgene insertion 1, Gianfranco Gennarini
• MGI ID: MGI:2445836
• Synonyms: TAG/F3
• Transgene: Tg(CNTN2-CNTN1)1Gnn Location: unknown
• Alliance: Tg(CNTN2-CNTN1)1Gnn page

Transgene origin

• Strain of Origin: (CBA x C57BL/10)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CNTN2-CNTN1)1Gnn expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CNTN1 (1272)

  Cntn1

  (MGI:105980)

• Mutation details: The transgene consists of the human CNTN2 proximal promoter and a full-length CNTN1 cDNA sequence. The CNTN2 portion includes exons 1-2. The promoter sequences were used to drive transgene expression the brain. Immunohistochemical analysis of postnatal day 4 animals showed transgene expression throughout most of the external granular layer (EGL). Expression of the transgene was confirmed by RT-PCR. (J:80098)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Five transgenic founders were created. Representative results were obtained from line TAG/F3.

References

• Original: J:80098 Bizzoca A, et al., Transgenic mice expressing F3/contactin from the TAG-1 promoter exhibit developmentally regulated changes in the differentiation of cerebellar neurons. Development. 2003 Jan;130(1):29-43
• All: 3 reference(s)