P2ry12^tm1Cjf
Targeted Allele Detail

Summary

• Symbol: P2ry12^tm1Cjf
• Name: purinergic receptor P2Y, G-protein coupled 12; targeted mutation 1, Carolyn J Foster
• MGI ID: MGI:2445936
• Synonyms: P2Y12^-, SP1999^-
• Gene: P2ry12 Location: Chr3:59123693-59170292 bp, - strand Genetic Position: Chr3, 29.01 cM
• Alliance: P2ry12^tm1Cjf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70017
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The endogenous locus was disrupted by homologous recombination of a neomycin selection cassette. An absence of transcript in homozygous mutant mice was demonstrated by Northern blot analysis of total brain RNA. (J:70017)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any P2ry12 Mutation: 41 strains or lines available

References

• Original: J:70017 Foster CJ, et al., Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs. J Clin Invest. 2001 Jun;107(12):1591-8
• All: 12 reference(s)