Hoxd13^tm3Ddu
Targeted Allele Detail

Summary

• Symbol: Hoxd13^tm3Ddu
• Name: homeobox D13; targeted mutation 3, Denis Duboule
• MGI ID: MGI:2445969
• Synonyms: EvD^GE1, Evx2/Hoxd13^tm1Ddu
• Gene: Hoxd13 Location: Chr2:74498654-74501943 bp, + strand Genetic Position: Chr2, 44.13 cM
• Alliance: Hoxd13^tm3Ddu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37211
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion, Nucleotide substitutions
• Mutation details: Translation of both the Evx2 and Hoxd13 loci was disrupted by the insertion of stop codons at base pairs 110 and 58 of the respective open reading frames. In addition, the targeting construct contained a floxed neo cassette inserted into the intergenic region as well as 153 bp deletion of Hoxd13. (J:37211)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxd13 Mutation: 24 strains or lines available

Notes

This allele exists only in mice carrying Evx2^tm3Ddu

References

• Original: J:37211 Herault Y, et al., Function of the Evx-2 gene in the morphogenesis of vertebrate limbs. EMBO J. 1996 Dec 2;15(23):6727-38
• All: 1 reference(s)