Evx2^tm2Ddu
Targeted Allele Detail

Summary

• Symbol: Evx2^tm2Ddu
• Name: even-skipped homeobox 2; targeted mutation 2, Denis Duboule
• MGI ID: MGI:2445970
• Synonyms: EvD^GE2, Evx2/Hoxd13^tm2Ddu
• Gene: Evx2 Location: Chr2:74483335-74489901 bp, - strand Genetic Position: Chr2, 44.13 cM
• Alliance: Evx2^tm2Ddu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37211
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: ES cells carrying Hoxd13^tm1Ddu were electroporated with the targeting vector (used to generate Evx2^tm1Ddu) that inserted a hygro selection cassette in exon 1. The intergenic region was left intact. (J:37211)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Evx2 Mutation: 19 strains or lines available

Notes

This allele exists only in mice carrying Hoxd13

References

• Original: J:37211 Herault Y, et al., Function of the Evx-2 gene in the morphogenesis of vertebrate limbs. EMBO J. 1996 Dec 2;15(23):6727-38
• All: 1 reference(s)