Tg(K5-Ptgs2)19Kmd
Transgene Detail

Summary

• Symbol: Tg(K5-Ptgs2)19Kmd
• Name: transgene insertion 19, Karin Muller-Decker
• MGI ID: MGI:2445978
• Synonyms: K5-COX-2/19, K5.COX-2/19
• Transgene: Tg(K5-Ptgs2)19Kmd Location: unknown
• Alliance: Tg(K5-Ptgs2)19Kmd page

Sparse hair and long nails in mice expressing Tg(K5-Ptgs2)

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: NMRI

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(K5-Ptgs2)19Kmd expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ptgs2 (MGI:97798)

• Mutation details: The transgene is composed of a full length Ptgs2 cDNA without the 3' untranslated region fused to a bovine keratin 5 (K5) promoter. Transgene expression was confirmed by RT-PCR analysis of stratified epithelial tissues. (J:70039)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Seven founder animals were constructed and bred successfully. The founders are designated lines 4, 19, 29, 663, 667, 675, and 678. Line 19 exhibits weak transgene expression.

References

• Original: J:70039 Neufang G, et al., Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7629-34
• All: 3 reference(s)