Hoxd^tm5Ddu
Targeted Allele Detail

Summary

• Symbol: Hoxd^tm5Ddu
• Name: homeobox D cluster; targeted mutation 5, Denis Duboule
• MGI ID: MGI:2445979
• Synonyms: C6cre, L4
• Gene: Hoxd Location: unknown Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45706
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Region IX, located in the intergenic region between Hoxd11 and Hoxd10, was disrupted by a 7 nt mutation in a nuclear receptor response element (NRRE). A floxed neo cassette that was included in the targeting construct was removed in vitro via cre mediated recombination, leaving a single loxP site downstream of region IX. (J:45706)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxd Mutation: 0 strains or lines available

References

• Original: J:45706 Gerard M, et al., In vivo targeted mutagenesis of a regulatory element required for positioning the Hoxd-11 and Hoxd-10 expression boundaries. Genes Dev. 1996 Sep 15;10(18):2326-34
• All: 2 reference(s)