Hoxd^tm11Ddu
Targeted Allele Detail

Summary

• Symbol: Hoxd^tm11Ddu
• Name: homeobox D cluster; targeted mutation 11, Denis Duboule
• MGI ID: MGI:2446018
• Synonyms: HoxD^13lacZ
• Gene: Hoxd Location: unknown Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66264
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An in frame lacZ followed by floxed neo was introduced into Hoxd13 locus of ES cells containing the Hoxd^tm5Ddu allele. The floxed neo cassette was excised in vitro leaving the lacZ reporter in Hoxd13 and the Hoxd11 and Hoxd12 genes flanked by the oppositely oriented loxP sites. (J:66264)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxd Mutation: 0 strains or lines available

References

• Original: J:66264 Kmita M, et al., Targeted inversion of a polar silencer within the HoxD complex re-allocates domains of enhancer sharing. Nat Genet. 2000 Dec;26(4):451-4
• All: 5 reference(s)