Hoxd^tm11.1Ddu
Targeted Allele Detail

Summary

• Symbol: Hoxd^tm11.1Ddu
• Name: homeobox D cluster; targeted mutation 11.1, Denis Duboule
• MGI ID: MGI:2446027
• Synonyms: HoxD^inv, invloxP
• Gene: Hoxd Location: unknown Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66264
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Inversion
• Hoxd^tm11.1Ddu involves 3 genes/genome features (Hoxd13, Hoxd12, Hoxd11) View all
• Mutation details: An inversion within the Hoxd cluster was achieved by cre mediated recombination of Hoxd^tm11Ddu which contained oppositely oriented loxP sites flanking Hoxd12 and Hoxd11. The resulting allele contained a lacZ reporter in Hoxd13 and Hoxd11 positioned 5' to Hoxd12. (J:66264)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxd Mutation: 0 strains or lines available

References

• Original: J:66264 Kmita M, et al., Targeted inversion of a polar silencer within the HoxD complex re-allocates domains of enhancer sharing. Nat Genet. 2000 Dec;26(4):451-4
• All: 5 reference(s)