Tg(SFTPC-MST1R)71Mhw
Transgene Detail

Summary

• Symbol: Tg(SFTPC-MST1R)71Mhw
• Name: transgene insertion 71, Ming-Hai Wang
• MGI ID: MGI:2446031
• Synonyms: SPCp-RON, Tg(SFTPC-MST1R)1Mhw
• Transgene: Tg(SFTPC-MST1R)71Mhw Location: unknown
• Alliance: Tg(SFTPC-MST1R)71Mhw page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(SFTPC-MST1R)71Mhw expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MST1R (4486)

  Mst1r

  (MGI:99614)

• Mutation details: The transgene consists of a human MST1R cDNA cloned between a human SFTPC promoter and SV40 polyadenylation signal. 3.7 kb of human SFTPC promoter sequences drives transgene expression in the lungs. Western blot analysis shows high transgene expression in the lung and no other tissues examined. (J:79080)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Three transgenic founder lines were established. Founder #35 carries 8 copies of the transgene, founder #36 carries 3 copies, and founder #71 carries 12 copies.

References

• Original: J:79080 Chen YQ, et al., Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation: oncogenic potential of RON in vivo. Oncogene. 2002 Sep 12;21(41):6382-6
• All: 1 reference(s)