Tg(BGLAP-cre)1Clem
Transgene Detail

Summary

• Symbol: Tg(BGLAP-cre)1Clem
• Name: transgene insertion 1, Thomas L Clemens
• MGI ID: MGI:2446069
• Synonyms: HOC-cre, OC-cre, OC-cre line 6, OCNCre, osteocalcin-Cre
• Transgene: Tg(BGLAP-cre)1Clem Location: unknown
• Alliance: Tg(BGLAP-cre)1Clem page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(BGLAP-cre)1Clem expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  BGLAP (632)

  Bglap	(MGI:88156)
  Bglap2	(MGI:88157)
  Bglap3	(MGI:88155)

• Mutation details: A human osteocalcin (BGLAP) promoter, driving expression in osteoblasts, fused to a cre recombinase gene was used for the transgene. The cre gene was modified to include a nuclear localization signal and human ACTB 3' untranslated region. Two lines were generated, 4 and 6. This allele represents line 6. Transgene expression was observed in the calvaria, femur, and vertebrae by Northern blot analysis. (J:80190)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	BGLAP (human) Summary of all recombinase alleles driven by BGLAP. Comparative matrix view of recombinase activities Alliance human BGLAP gene page

Disease models

Expression

In Mice Carrying this Mutation:

104056 assay results 2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Two transgenic lines, designated 4 and 6, were established.

References

• Original: J:80190 Zhang M, et al., Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization. J Biol Chem. 2002 Nov 15;277(46):44005-12
• All: 153 reference(s)