Ripk2^tm1Ghc
Targeted Allele Detail

Summary

• Symbol: Ripk2^tm1Ghc
• Name: receptor (TNFRSF)-interacting serine-threonine kinase 2; targeted mutation 1, Genhong Cheng
• MGI ID: MGI:2446070
• Synonyms: Rip2^-
• Gene: Ripk2 Location: Chr4:16122733-16163647 bp, - strand Genetic Position: Chr4, 6.7 cM
• Alliance: Ripk2^tm1Ghc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75401
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Western blot analysis of splenocyte extracts indicated an absence of normal protein in homozygous mutant mice. (J:75401)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Ripk2^tm1Ghc/Ripk2^tm1Ghc	involves: 129S4/SvJae * C57BL/6

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
cellular	√
decreased T cell proliferation	√
hematopoietic system	√
decreased T cell proliferation	√
decreased IgG2a level	√
immune system	√
decreased T cell proliferation	√
decreased IgG2a level	√
decreased interferon-gamma secretion	√
increased susceptibility to infection	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ripk2 Mutation: 35 strains or lines available

References

• Original: J:75401 Chin AI, et al., Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature. 2002 Mar 14;416(6877):190-4
• All: 14 reference(s)