Rdh5tm1Wsb
Targeted Allele Detail
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Symbol: |
Rdh5tm1Wsb |
Name: |
retinol dehydrogenase 5; targeted mutation 1, William S Blaner |
MGI ID: |
MGI:2446073 |
Synonyms: |
cRDH- |
Gene: |
Rdh5 Location: Chr10:128749457-128755906 bp, - strand Genetic Position: Chr10, 77.19 cM
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Alliance: |
Rdh5tm1Wsb page
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Germline Transmission: |
Earliest citation of germline transmission:
J:75693
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129/Sv
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The majority of exon 2 and all of exon 3 were replaced by a neomycin selection cassette inserted by homologous recombination. The deleted region encoded approximately two thirds of the wild-type protein. While in situ hybridization of homozygous mutant eye sections using a probe for the targeted region indicated an absence of normal transcript, a truncated transcript was identified by Northern blot analysis.
(J:75693)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Rdh5 Mutation: |
11 strains or lines available
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Original: |
J:75693 Shang E, et al., Targeted disruption of the mouse cis-retinol dehydrogenase gene. Visual and nonvisual functions. J Lipid Res. 2002 Apr;43(4):590-7 |
All: |
1 reference(s) |
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