Tg(Cga-LHB/CGB)94Jhn
Transgene Detail

Summary

• Symbol: Tg(Cga-LHB/CGB)94Jhn
• Name: transgene insertion 94, John H Nilson
• MGI ID: MGI:2446075
• Synonyms: LHbeta-CTP, LHbetaCTP, LH-CTP, Tg(bLHbeta-CTP)94Jhn, Tg-LHbeta
• Transgene: Tg(Cga-LHB/CGB)94Jhn Location: unknown
• Alliance: Tg(Cga-LHB/CGB)94Jhn page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Cga-LHB/CGB)94Jhn expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  cattle	LHB (280839)

• Mutation details: The transgene contains the entire bovine luteinizing hormone beta (LHB) cDNA fused to 87 bp encoding the c-terminal peptide (CTP) of the human chorionic gonadotropin beta subunit (CGB). The bovine glycoprotein hormone alpha subunit (CGA) promoter (positions -315 to +45) was used to drive expression in gonadotropes. Immunohistochemical analysis confirmed both LHB and CTP expression in the pituitaries. (J:55157)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Cga-LHB/CGB)94Jhn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:55157 Risma KA, et al., Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1322-6
• All: 23 reference(s)