Tnfsf14^tm1Wwh
Targeted Allele Detail

Summary

• Symbol: Tnfsf14^tm1Wwh
• Name: tumor necrosis factor (ligand) superfamily, member 14; targeted mutation 1, Wayne W Hancock
• MGI ID: MGI:2446076
• Synonyms: LIGHT^-
• Gene: Tnfsf14 Location: Chr17:57496492-57501177 bp, - strand Genetic Position: Chr17, 29.71 cM, cytoband D-E1
• Alliance: Tnfsf14^tm1Wwh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75705
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: An 800 nt fragment containing a portion of exon 1 including the translational start codon was replaced with a neomycin selection cassette. Transcript was undetected in homozygous mutant mice by Northern blot analysis of liver RNA using a probe for the entire coding region. (J:75705)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfsf14 Mutation: 27 strains or lines available

References

• Original: J:75705 Ye Q, et al., Modulation of LIGHT-HVEM costimulation prolongs cardiac allograft survival. J Exp Med. 2002 Mar 18;195(6):795-800
• All: 1 reference(s)