S100a1^tm1Jhh
Targeted Allele Detail

Summary

• Symbol: S100a1^tm1Jhh
• Name: S100 calcium binding protein A1; targeted mutation 1, Jorg Heierhorst
• MGI ID: MGI:2446086
• Synonyms: S100A1^-
• Gene: S100a1 Location: Chr3:90418341-90421637 bp, - strand Genetic Position: Chr3, 39.24 cM, cytoband F1-F2
• Alliance: S100a1^tm1Jhh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75781
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced with a PGK-neo cassette via homologous recombination. The absence of endogenous protein was demonstrated by Western blot and immunohistochemical analyses of homozygous mutant mice. (J:75781)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any S100a1 Mutation: 12 strains or lines available

References

• Original: J:75781 Du XJ, et al., Impaired cardiac contractility response to hemodynamic stress in S100A1-deficient mice. Mol Cell Biol. 2002 Apr;22(8):2821-9
• All: 7 reference(s)