Crkl^tm1Hkp
Targeted Allele Detail

Summary

• Symbol: Crkl^tm1Hkp
• Name: v-crk avian sarcoma virus CT10 oncogene homolog-like; targeted mutation 1, Nora Heisterkamp
• MGI ID: MGI:2446094
• Synonyms: crkl-
• Gene: Crkl Location: Chr16:17269851-17305298 bp, + strand Genetic Position: Chr16, 10.82 cM
• Alliance: Crkl^tm1Hkp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76680
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. (J:76680)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Crkl Mutation: 17 strains or lines available

References

• Original: J:76680 Hemmeryckx B, et al., BCR/ABL P190 transgenic mice develop leukemia in the absence of Crkl. Oncogene. 2002 May 9;21(20):3225-31
• All: 2 reference(s)