Tg(Fabp2-Arg1)1Wla
Transgene Detail

Summary

• Symbol: Tg(Fabp2-Arg1)1Wla
• Name: transgene insertion 1, Wouters H Lamers
• MGI ID: MGI:2446302
• Synonyms: F/A-2⁺
• Transgene: Tg(Fabp2-Arg1)1Wla Location: unknown
• Alliance: Tg(Fabp2-Arg1)1Wla page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Fabp2-Arg1)1Wla expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Arg1 (29221)

  Arg1	(MGI:88070)

• Mutation details: The transgene consists of a rat Fabp2 promoter/enhancer (-1178 to +28 bp), a 520 bp fragment of rat Arg1 cDNA encoding exons 1-4, and a 2400 bp fragment of rat Arg1 genomic DNA encoding exons 5-8. (J:80556)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available

Notes

Two transgenic founders were created, F/A-1 and F/A-2. Southern blot analysis revealed that both founders carried 5-6 integrated copies of the transgene.

References

• Original: J:80556 de Jonge WJ, et al., Overexpression of arginase I in enterocytes of transgenic mice elicits a selective arginine deficiency and affects skin, muscle, and lymphoid development. Am J Clin Nutr. 2002 Jul;76(1):128-40
• All: 5 reference(s)