Tg(Prrx1-Hand2)5Eno
Transgene Detail
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Symbol: |
Tg(Prrx1-Hand2)5Eno |
Name: |
transgene insertion 5, Eric N Olson |
MGI ID: |
MGI:2446342 |
Synonyms: |
RRR109-111EDE, Tg(Pr2x1-Hand2)5Eno |
Transgene: |
Tg(Prrx1-Hand2)5Eno Location: unknown
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Alliance: |
Tg(Prrx1-Hand2)5Eno page
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Prrx1-Hand2)5Eno expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Hand2 (MGI:103580) |
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Mutation details: The transgene consists of a mouse Prrx1 promoter fused to a mutant Hand2 cDNA with the following amino acid subsitutions: arginine to glutamic acid at residues 109 (R109E) and 111 (R111E), and arginine to aspartic acid at residue 110 (R110D). The mouse Prrx1 promoter was used to drive transgene expression in the forelimb bud and anterior mesoderm of the hindlimb in E10.5 embryos. The Hand2 construct also contains an N-terminal Myc epitope tag and a 3' human growth hormone polyadenylation signal.
(J:80030)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:80030 McFadden DG, et al., Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding. Development. 2002 Jul;129(13):3077-88 |
All: |
1 reference(s) |
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