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Tg(Prrx1-Hand2)5Eno
Transgene Detail
Summary
Symbol: Tg(Prrx1-Hand2)5Eno
Name: transgene insertion 5, Eric N Olson
MGI ID: MGI:2446342
Synonyms: RRR109-111EDE, Tg(Pr2x1-Hand2)5Eno
Transgene: Tg(Prrx1-Hand2)5Eno  Location: unknown  
Alliance: Tg(Prrx1-Hand2)5Eno page
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Prrx1-Hand2)5Eno expresses 1 gene
 
Mutation detailsThe transgene consists of a mouse Prrx1 promoter fused to a mutant Hand2 cDNA with the following amino acid subsitutions: arginine to glutamic acid at residues 109 (R109E) and 111 (R111E), and arginine to aspartic acid at residue 110 (R110D). The mouse Prrx1 promoter was used to drive transgene expression in the forelimb bud and anterior mesoderm of the hindlimb in E10.5 embryos. The Hand2 construct also contains an N-terminal Myc epitope tag and a 3' human growth hormone polyadenylation signal. (J:80030)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:80030 McFadden DG, et al., Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding. Development. 2002 Jul;129(13):3077-88
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory