Gnaq^tm2.1Soff
Targeted Allele Detail

Summary

• Symbol: Gnaq^tm2.1Soff
• Name: guanine nucleotide binding protein, alpha q polypeptide; targeted mutation 2.1, Stefan Offermanns
• MGI ID: MGI:2446363
• Synonyms: Galphaq, Gna1^delta
• Gene: Gnaq Location: Chr19:16110195-16364827 bp, + strand Genetic Position: Chr19, 11.01 cM
• Alliance: Gnaq^tm2.1Soff page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77461
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Deletion of the floxed region containing exon 6 was achieved via in vivo cre mediated recombination of Gnaq^tm2Soff. (J:77461)

Expression

In Mice Carrying this Mutation:

22 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gnaq Mutation: 24 strains or lines available

References

• Original: J:77461 Wettschureck N, et al., Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes. Nat Med. 2001 Nov;7(11):1236-40
• All: 4 reference(s)