Med24^tm1Rgr
Targeted Allele Detail

Summary

• Symbol: Med24^tm1Rgr
• Name: mediator complex subunit 24; targeted mutation 1, Robert G Roeder
• MGI ID: MGI:2446465
• Synonyms: Trap100^-
• Gene: Med24 Location: Chr11:98595423-98620245 bp, - strand Genetic Position: Chr11, 62.46 cM
• Alliance: Med24^tm1Rgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77765
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The endogenous locus was disrupted by the in frame insertion of lacZ and neo immediately after the translational start codon. Normal transcript was undetected by Northern blot analysis of homozygous mutant mice. Whole mount staining of mutant embryos indicated that the expression of lacZ was driven by the endogenous promoter. (J:77765)

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Med24 Mutation: 35 strains or lines available

References

• Original: J:77765 Ito M, et al., The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. EMBO J. 2002 Jul 1;21(13):3464-75
• All: 2 reference(s)