Trrap^tm1Zqw
Targeted Allele Detail

Summary

• Symbol: Trrap^tm1Zqw
• Name: transformation/transcription domain-associated protein; targeted mutation 1, Zhao-Qi Wang
• MGI ID: MGI:2446467
• Synonyms: Trrap^t
• Gene: Trrap Location: Chr5:144704547-144796588 bp, + strand Genetic Position: Chr5, 84.77 cM
• Alliance: Trrap^tm1Zqw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71950
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The exon encoding the beginning of the protein's kinase-like domain was flanked upstream by a single loxP site and downstream by a loxP-flanked neomycin resistance-thymidine kinase (neo^r-tk) cassette inserted into the intron corresponding to intron 64 of the orthologous human gene. The absence of homozygous progeny from crosses of mice heterozygous for this allele demonstrates functional disruption of the gene or protein. (J:71950)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trrap Mutation: 162 strains or lines available

Notes

No mice derived from ES cells bearing the "floxed" allele from which only the neo-tk cassette had been deleted were recovered.

References

• Original: J:71950 Herceg Z, et al., Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression. Nat Genet. 2001 Oct;29(2):206-11
• All: 3 reference(s)