Galr1^tm1Tpi
Targeted Allele Detail

Summary

• Symbol: Galr1^tm1Tpi
• Name: galanin receptor 1; targeted mutation 1, Tiina Pauline Iismaa
• MGI ID: MGI:2446477
• Synonyms: Galr1^-, GAL-R1-
• Gene: Galr1 Location: Chr18:82410621-82424902 bp, - strand Genetic Position: Chr18, 55.78 cM, cytoband E3-E4
• Alliance: Galr1^tm1Tpi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80441
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted 780 bp into the endogenous locus via homologous recombination. Normal transcript was undetected in homozygous mutant mice by RT-PCR analysis. (J:80441, J:92467)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Galr1 Mutation: 31 strains or lines available

References

• Original: J:80441 Jacoby AS, et al., Critical role for GALR1 galanin receptor in galanin regulation of neuroendocrine function and seizure activity. Brain Res Mol Brain Res. 2002 Nov 15;107(2):195-200
• All: 18 reference(s)