Reg1^tm1Okam
Targeted Allele Detail

Summary

• Symbol: Reg1^tm1Okam
• Name: regenerating islet-derived 1; targeted mutation 1, Hiroshi Okamoto
• MGI ID: MGI:2446480
• Synonyms: Reg^-
• Gene: Reg1 Location: Chr6:78402966-78405651 bp, + strand Genetic Position: Chr6, 34.77 cM, cytoband C-D
• Alliance: Reg1^tm1Okam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80444
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2 was disrupted by a neomycin selection cassette inserted by homologous recombination. Neither transcript nor protein was detected by Northern or Western blot analyses of homozygous mutant mice. (J:80444)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Reg1 Mutation: 15 strains or lines available

References

• Original: J:80444 Unno M, et al., Production and characterization of Reg knockout mice: reduced proliferation of pancreatic beta-cells in Reg knockout mice. Diabetes. 2002 Dec;51 Suppl 3:S478-83
• All: 5 reference(s)