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Hcsttm1.1Cln
Targeted Allele Detail
Summary
Symbol: Hcsttm1.1Cln
Name: hematopoietic cell signal transducer; targeted mutation 1.1, Marco Colonna
MGI ID: MGI:2446491
Synonyms: DAP10-
Gene: Hcst  Location: Chr7:30117137-30119279 bp, - strand  Genetic Position: Chr7, 17.45 cM
Alliance: Hcsttm1.1Cln page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80426
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThis allele is derived from Hcsttm1Cln by mating mutant animals to cre deleter strain TgN(CMV-cre)1Cgn. Resulting progeny are deleted for the floxed neo cassette and contain a single loxP site in place of exon 1 and intron 1. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis of lysates from NK cells and CD8+ cells. (J:80426)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hcst Mutation:  9 strains or lines available
References
Original:  J:80426 Gilfillan S, et al., NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat Immunol. 2002 Dec;3(12):1150-5
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory