Dkc1^tm1Bsl
Targeted Allele Detail

Summary

• Symbol: Dkc1^tm1Bsl
• Name: dyskeratosis congenita 1, dyskerin; targeted mutation 1, Monica Bessler
• MGI ID: MGI:2446497
• Synonyms: DC1, Dkc1^lox
• Gene: Dkc1 Location: ChrX:74139460-74153382 bp, + strand Genetic Position: ChrX, 38.15 cM
• Alliance: Dkc1^tm1Bsl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80494
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The coding regions of exons 12 through 15 were flanked by a single loxP site inserted into intron 11 and an IRES-neomycin selection cassette containing a 3' loxP site inserted into the noncoding region of exon 15. Mice carrying this allele were utilized to generate Dkc1^tm1.1Bsl. (J:80494)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dkc1 Mutation: 2 strains or lines available

References

• Original: J:80494 He J, et al., Targeted disruption of Dkc1, the gene mutated in X-linked dyskeratosis congenita, causes embryonic lethality in mice. Oncogene. 2002 Oct 31;21(50):7740-4
• All: 3 reference(s)