Ccs^tm1Pcw
Targeted Allele Detail

Summary

• Symbol: Ccs^tm1Pcw
• Name: copper chaperone for superoxide dismutase; targeted mutation 1, Philip C Wong
• MGI ID: MGI:2446505
• Synonyms: CCS^-
• Gene: Ccs Location: Chr19:4875394-4889326 bp, - strand Genetic Position: Chr19, 4.11 cM
• Alliance: Ccs^tm1Pcw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80627
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.5 kb genomic fragment containing the first two exons, part of the promoter, and the first two introns of the gene was replaced with a neomycin selection cassette inserted by homologous recombination. No protein was detected by Western blot analysis of homozygous mutant mice. (J:80627)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccs Mutation: 26 strains or lines available

References

• Original: J:80627 Wong PC, et al., Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2886-91
• All: 5 reference(s)