Il21r^tm1Wjl
Targeted Allele Detail

Summary

• Symbol: Il21r^tm1Wjl
• Name: interleukin 21 receptor; targeted mutation 1, Warren J Leonard
• MGI ID: MGI:2446509
• Synonyms: IL-21R^-
• Gene: Il21r Location: Chr7:125202601-125232742 bp, + strand Genetic Position: Chr7, 68.98 cM, cytoband F4
• Alliance: Il21r^tm1Wjl page

IL-21R deficiency prevents renal disease and mortality characteristic of BXSB-Yaa mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80474
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The endogenous locus was disrupted by the insertion of a neomycin selection cassette. Sequence encoding the majority of the signal peptide through the transmembrane domain was replaced by neo, resulting in a frameshift mutation affecting sequence encoding the cytoplasmic domain. Transcript was undetected by RT-PCR analysis of thymocytes obtained from homozygous mutant mice. (J:80474, J:95221)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 6 strains available Cell Lines: 0 lines available
• Carrying any Il21r Mutation: 42 strains or lines available

References

• Original: J:80474 Ozaki K, et al., A critical role for IL-21 in regulating immunoglobulin production. Science. 2002 Nov 22;298(5598):1630-4
• All: 68 reference(s)