Il3^tm1Glli
Targeted Allele Detail

Summary

• Symbol: Il3^tm1Glli
• Name: interleukin 3; targeted mutation 1, Stephen J Galli
• MGI ID: MGI:2446538
• Synonyms: Il-3-
• Gene: Il3 Location: Chr11:54156129-54158103 bp, - strand Genetic Position: Chr11, 32.13 cM, cytoband B1
• Alliance: Il3^tm1Glli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80640
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 5' portion of exon 3 was replaced by the insertion of a neomycin selection cassette. The absence of normal protein was indicated by ELISA and proliferative studies using a myeloid cell line. (J:80640)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Il3^tm1Glli

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il3 Mutation: 31 strains or lines available

References

• Original: J:80640 Mach N, et al., Involvement of interleukin-3 in delayed-type hypersensitivity. Blood. 1998 Feb 1;91(3):778-83
• All: 31 reference(s)