Tg(BGLAP-PTN)1Thg
Transgene Detail

Summary

• Symbol: Tg(BGLAP-PTN)1Thg
• Name: transgene insertion 1, Tamotsu Hashimoto-Gotoh
• MGI ID: MGI:2446540
• Synonyms: hosf⁶, HPoc-Hosf1-6, PTN-Tg
• Transgene: Tg(BGLAP-PTN)1Thg Location: unknown
• Alliance: Tg(BGLAP-PTN)1Thg page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(BGLAP-PTN)1Thg expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PTN (5764)

  Ptn	(MGI:97804)

• Tg(BGLAP-PTN)1Thg expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  BGLAP (632)

  Bglap	(MGI:88156)
  Bglap2	(MGI:88157)
  Bglap3	(MGI:88155)

• Mutation details: A human PTN gene directed by a human BGLAP promoter that directs expression in osteoblasts and maturing chondrocytes was used for the transgene. (J:80636)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Two transgenic founders were created. One founder, designated HPoc-Hosf1-6, carries 6 integrated copies of the transgene and was used for phenotypic analysis.

References

• Original: J:80636 Masuda H, et al., Bone mass loss due to estrogen deficiency is compensated in transgenic mice overexpressing human osteoblast stimulating factor-1. Biochem Biophys Res Commun. 1997 Sep 18;238(2):528-33
• All: 8 reference(s)