Trps1^tm1Shiv
Targeted Allele Detail

Summary

• Symbol: Trps1^tm1Shiv
• Name: transcriptional repressor GATA binding 1; targeted mutation 1, Ramesh A Shivdasani
• MGI ID: MGI:2446569
• Synonyms: TRPS^{delta neogt}
• Gene: Trps1 Location: Chr15:50518148-50753859 bp, - strand Genetic Position: Chr15, 19.18 cM
• Alliance: Trps1^tm1Shiv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80615
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4, which encodes the GATA-type zinc finger and 15 additional amino acids, was replaced by a floxed neomycin selection cassette inserted by homologous recombination. Mice carrying this allele were bred with transgenic mice expressing cre recombinase to generate Trps1tm1.1Shiv. (J:80615)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trps1 Mutation: 64 strains or lines available

References

• Original: J:80615 Malik TH, et al., Deletion of the GATA domain of TRPS1 causes an absence of facial hair and provides new insights into the bone disorder in inherited tricho-rhino-phalangeal syndromes. Mol Cell Biol. 2002 Dec;22(24):8592-600
• All: 2 reference(s)