Trps1^tm1.1Shiv
Targeted Allele Detail

Summary

• Symbol: Trps1^tm1.1Shiv
• Name: transcriptional repressor GATA binding 1; targeted mutation 1.1, Ramesh A Shivdasani
• MGI ID: MGI:2446570
• Synonyms: Trps1^-, TRPS1^{delta gt}
• Gene: Trps1 Location: Chr15:50518148-50753859 bp, - strand Genetic Position: Chr15, 19.18 cM
• Alliance: Trps1^tm1.1Shiv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80615
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The floxed neo cassette that replaced exon 4 was excised in vivo via cre mediated recombination. The deleted region encoded the GATA-type zinc finger domain. RT-PCR of homozygous mutant mice identified transcript lacking the targeted nucleotides, encoding amino acids 888 through 928, however it retained in frame sequence encoding the nuclear localization singal (amino acids 946 through 952). (J:80615)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	20 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Trps1^tm1.1Shiv

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trps1 Mutation: 64 strains or lines available

References

• Original: J:80615 Malik TH, et al., Deletion of the GATA domain of TRPS1 causes an absence of facial hair and provides new insights into the bone disorder in inherited tricho-rhino-phalangeal syndromes. Mol Cell Biol. 2002 Dec;22(24):8592-600
• All: 8 reference(s)