Stam^tm2Sug
Targeted Allele Detail

Summary

• Symbol: Stam^tm2Sug
• Name: signal transducing adaptor molecule (SH3 domain and ITAM motif) 1; targeted mutation 2, Kazuo Sugamura
• MGI ID: MGI:2446572
• Synonyms: STAM1^flox
• Gene: Stam Location: Chr2:14078912-14152351 bp, + strand Genetic Position: Chr2, 10.36 cM, cytoband A2-B
• Alliance: Stam^tm2Sug page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80617
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A region containing exons 3 and 4 was flanked by an upstream single loxP site and a downstream neo cassette immediately followed by a single loxP site. (J:80617)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stam Mutation: 43 strains or lines available

References

• Original: J:80617 Yamada M, et al., Signal-Transducing Adaptor Molecules STAM1 and STAM2 Are Required for T-Cell Development and Survival. Mol Cell Biol. 2002 Dec;22(24):8648-58
• All: 1 reference(s)