Slc11a1^tm1Mcg
Targeted Allele Detail

Summary

• Symbol: Slc11a1^tm1Mcg
• Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1; targeted mutation 1, McGill University
• MGI ID: MGI:2446573
• Synonyms: Nramp1-
• Gene: Slc11a1 Location: Chr1:74414354-74425221 bp, + strand Genetic Position: Chr1, 38.54 cM
• Alliance: Slc11a1^tm1Mcg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28278
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 500 nt fragment containing a portion of exon 7 and all of exon 8 was replaced with a neomycin selection cassette inserted by homologous recombination. Whereas Northern blot analyses showed an absence of normal transcript, aberrant transcripts containing neo sequence were detected in homozygous mutant mice. Translation of the mutant transcripts was expected to result in truncated peptides lacking 8 of the 12 endogenous transmembrane domains. (J:28278)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc11a1 Mutation: 40 strains or lines available

References

• Original: J:28278 Vidal S, et al., The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene. J Exp Med. 1995 Sep 1;182(3):655-66
• All: 20 reference(s)