Pik3cd^tm1Jni
Targeted Allele Detail

Summary

• Symbol: Pik3cd^tm1Jni
• Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; targeted mutation 1, James N Ihle
• MGI ID: MGI:2446574
• Synonyms: p110delta^-, PI3Kdelta^-
• Gene: Pik3cd Location: Chr4:149733625-149787023 bp, - strand Genetic Position: Chr4, 80.15 cM
• Alliance: Pik3cd^tm1Jni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80614
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.6 kb fragment extending from within exon 2 through exon 6 was replaced with a neomycin selection cassette inserted by homologous recombination. Western blot analysis of splenic lysates indicated an absence of endogenous protein in homozygous mutant mice. (J:80614)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pik3cd Mutation: 45 strains or lines available

References

• Original: J:80614 Jou ST, et al., Essential, Nonredundant Role for the Phosphoinositide 3-Kinase p110delta in Signaling by the B-Cell Receptor Complex. Mol Cell Biol. 2002 Dec;22(24):8580-91
• All: 13 reference(s)