Ebf2^tm1Ggc
Targeted Allele Detail

Summary

• Symbol: Ebf2^tm1Ggc
• Name: early B cell factor 2; targeted mutation 1, Giacomo Consalez
• MGI ID: MGI:2446575
• Synonyms: Ebf2-
• Gene: Ebf2 Location: Chr14:67470741-67668367 bp, + strand Genetic Position: Chr14, 34.63 cM, cytoband D-E1
• Alliance: Ebf2^tm1Ggc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80220
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 5.2 kb fragment containing the coding regions of the first five exons was replaced with cassette containing lacZ immediately followed by a floxed neo. The deleted region included sequence encoding the majority of the DNA binding domain. Mice carrying this allele were crossed with cre transgenic mice to generate Ebf2tm1.1Ggc. (J:80220)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ebf2 Mutation: 30 strains or lines available

References

• Original: J:80220 Corradi A, et al., Hypogonadotropic hypogonadism and peripheral neuropathy in Ebf2-null mice. Development. 2003 Jan;130(2):401-10
• All: 5 reference(s)