Tg(KRT14-cre/ERT)20Efu
Transgene Detail

Summary

• Symbol: Tg(KRT14-cre/ERT)20Efu
• Name: transgene insertion 20, Elaine Fuchs
• MGI ID: MGI:2446606
• Synonyms: K14CREER, K14-CreERT, K14-CreER^tam, K14CreERTam, Ker14-CreERT, Tg(KRT14-cre/Esr1)2Efu
• Transgene: Tg(KRT14-cre/ERT)20Efu Location: unknown
• Alliance: Tg(KRT14-cre/ERT)20Efu page

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(KRT14-cre/ERT)20Efu expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  KRT14 (3861)

  Krt14

  (MGI:96688)

• Mutation details: Expression of a tamoxifen-inducible form of a Cre recombinase and estrogen receptor fusion protein in the basal layer of the epidermis, the outer root sheath of the hair follicle and the oral epithelium, driven by the human keratin 14 promoter (KRT14). The promoter is active by embryonic day 14.5 (E14.5). (J:56822, J:204651)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	KRT14 (human) Summary of all recombinase alleles driven by KRT14. Comparative matrix view of recombinase activities Alliance human KRT14 gene page

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(KRT14-cre/ERT)20Efu

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available

References

• Original: J:56822 Vasioukhin V, et al., The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8551-6
• All: 221 reference(s)