Tg(Camk2a-Fyn)1Kndl
Transgene Detail

Summary

• Symbol: Tg(Camk2a-Fyn)1Kndl
• Name: transgene insertion 1, Eric R Kandel
• MGI ID: MGI:2446639
• Synonyms: N8
• Transgene: Tg(Camk2a-Fyn)1Kndl Location: unknown
• Alliance: Tg(Camk2a-Fyn)1Kndl page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Camk2a-Fyn)1Kndl expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Fyn (MGI:95602)	Expresses Fyn (isoform B) cDNA

• Tg(Camk2a-Fyn)1Kndl expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Camk2a (MGI:88256)

• Mutation details: An Fyn (isoform B) cDNA and Camk2a promoter were used for the transgene. Transgene expression was confirmed in the forebrain of 1-month old transgenic animals by Northern blot and in situ hybridization. Transgenic RNA is expressed at 4 times the level of endogenous Fyn RNA. 8 kb of Camk2a promoter sequences directs transgene expression in postnatal forebrain neurons. (J:80637)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:80637 Kojima N, et al., Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4761-5
• All: 13 reference(s)