Tg(Prnp)37Jcol
Transgene Detail

Summary

• Symbol: Tg(Prnp)37Jcol
• Name: transgene insertion 37, John Collinge
• MGI ID: MGI:2446659
• Synonyms: MloxP, tg37
• Transgene: Tg(Prnp)37Jcol Location: unknown
• Alliance: Tg(Prnp)37Jcol page

Transgene origin

• Strain of Origin: mixed

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp)37Jcol expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Prnp (MGI:97769)

• Mutation details: A transgenic construct was generated by inserting the Prnp open reading frame flanked by loxP sites into a cosmid vector. The regulatory sequences contained within cosmid CosSHaTet drove expression in the brain. Western blot analysis of of the founder line showed overexpression of Prp in brain tissue. (J:74652)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

The founder line contained between 5 and 7 copies of the transgenic construct. Eggs of mixed background involve: 129/Sv * C57BL * FVB/N.

References

• Original: J:74652 Mallucci GR, et al., Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration. EMBO J. 2002 Feb 1;21(3):202-10
• All: 12 reference(s)