Datd^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Datd^DBA/2J
• Name: dopamine transporter density; DBA/2J
• MGI ID: MGI:2446804
• QTL: Datd Location: Chr19:15339699-15340234 bp Genetic Position: Chr19, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased dopamine transporter density compared to C57BL/6J. (J:70962)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:70962

Genome scan was performed on 21 BXD (B = C57BL/6J, D = DBA/2J) recombinant inbred (RI) strains to identify loci affecting dopamine transporter (DAT) density in the neotriatum. Progenitor strain DBA/2J exhibits 50% more DAT binding sites in the neostriatum than progenitor strain C57BL/6J. A significant locus, Datd (dopamine transporter density), mapped to mouse Chromosome 19 from 8 cM - 11 cM with a LOD score of 4.7 in association with marker Pomc-ps1 at approximately 9 cM. DBA/2J-derived alleles confer increased DAT density at Datd. Datd may also be associated with psychostimulant-induced activity and thermal response to cocaine and methamphetamines. Suggestive loci associated with DAT density mapped to mouse Chromosome 4 (P = 0.008 at Pmv19), mouse Chromosome 7 (P = 0.005 at Xmmv76), mouse Chromosome 8 (P = 0.003 at D8Ncvs52 and P = 0.008 at Mpmv21), mouse Chromosome 12 (P = 0.006 at D12Ncvs49), and mouse Chromosome 16 (P = 0.0017 at D16Mit5).

References

• Original: J:70962 Janowsky A, et al., Mapping genes that regulate density of dopamine transporters and correlated behaviors in recombinant inbred mice. J Pharmacol Exp Ther. 2001 Aug;298(2):634-43
• All: 1 reference(s)