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DatdC57BL/6J
QTL Variant Detail
Summary
QTL variant: DatdC57BL/6J
Name: dopamine transporter density; C57BL/6J
MGI ID: MGI:2446805
QTL: Datd  Location: Chr19:15339699-15340234 bp  Genetic Position: Chr19, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers decreased dopamine transporter density.
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:70962

Genome scan was performed on 21 BXD (B = C57BL/6J, D = DBA/2J) recombinant inbred (RI) strains to identify loci affecting dopamine transporter (DAT) density in the neotriatum. Progenitor strain DBA/2J exhibits 50% more DAT binding sites in the neostriatum than progenitor strain C57BL/6J. A significant locus, Datd (dopamine transporter density), mapped to mouse Chromosome 19 from 8 cM - 11 cM with a LOD score of 4.7 in association with marker Pomc-ps1 at approximately 9 cM. DBA/2J-derived alleles confer increased DAT density at Datd. Datd may also be associated with psychostimulant-induced activity and thermal response to cocaine and methamphetamines. Suggestive loci associated with DAT density mapped to mouse Chromosome 4 (P = 0.008 at Pmv19), mouse Chromosome 7 (P = 0.005 at Xmmv76), mouse Chromosome 8 (P = 0.003 at D8Ncvs52 and P = 0.008 at Mpmv21), mouse Chromosome 12 (P = 0.006 at D12Ncvs49), and mouse Chromosome 16 (P = 0.0017 at D16Mit5).

References
Original:  J:70962 Janowsky A, et al., Mapping genes that regulate density of dopamine transporters and correlated behaviors in recombinant inbred mice. J Pharmacol Exp Ther. 2001 Aug;298(2):634-43
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory