Hcs6^{M. spretus}
QTL Variant Detail

Summary

• QTL variant: Hcs6^{M. spretus}
• Name: hepatocarcinogenesis susceptibility 6; M. spretus
• MGI ID: MGI:2446816
• QTL: Hcs6 Location: unknown Genetic Position: Chr19, cM position of peak correlated region/allele: 38.15 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: M. spretus

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased hepatocarcinogenesis susceptibility compared to C3H/He and C57BL/6ByJ. (J:20738)

Notes

Candidate Genes

J:80006

In order to elicudate whether or not Scd1 is the gene responsible for hepatocarcinogenesis susceptibility QTL Hcs6, 179 animals from a (BALB/c x C3H/HeJ)F2 cross were typed for markers on mouse Chromosome 19 to observe the segregation of Scd1 and Hcs6. No linkage was observed, therefore the gene responsible for Hcs6 is not Scd1.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:20738

Quantitative trait locus analysis was used to find loci involved in hepatocarcinogenesis susceptibility in 106 male progeny from the (C3H/He x M. spretus)F1 x C57BL/6JBy backcross. One locus, Hcs6, maps to Chromosome 19 in the region of D19Mit27 with a peak LOD score of 2.8 and P = 0.0004.

References

• Original: J:20738 Manenti G, et al., Multiple loci affect genetic predisposition to hepatocarcinogenesis in mice. Genomics. 1994 Sep 1;23(1):118-24
• All: 1 reference(s)