Lfp2^MSM
QTL Variant Detail

Summary

• QTL variant: Lfp2^MSM
• Name: long free running period 2; MSM
• MGI ID: MGI:2446822
• QTL: Lfp2 Location: Chr19:35295162-35295381 bp Genetic Position: Chr19, cM position of peak correlated region/allele: 29.79 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: MSM

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:68402

QTLs associated with free running period were provisionally mapped in 289 animals from a (CS x C57BL/6)F2 intercross and confirmed in 192 animals from a (CS x MSM)F2 intercross. Parental strain CS exhibits unstable free running patterns and spontaneous rhythm splitting whereas parental strains C57BL/6 and MSM exhibit regular running patterns.

QTLs for long free running period were identified on mouse Chromosome 19 in the

(CS x MSM)F2 intercross:

Lfp1 maps from 50 cM - tel with a LOD = 4.61 at D19Mit33;

Lfp2 maps from 26 cM - 47 cM with a LOD = 4.26 at D19Mit5;

and Lfp3 maps from 0 cM - 26 cM with a suggestive LOD = 3.85 at D19Mit32.

[See Fig 5.]

CS-derived alleles appear to increase the length of the free running period at Lfp1, Lfp2, and Lfp3 in a recessively inherited fashion. No obvious candidate genes were identified at these loci.

A suggestive locus mapped to mouse Chromosome 12 from 25 cM - 45 cM with LOD = 3.24 at D12Mit4 in the (CS x C57BL/6)F2 intercross but did not reach statistical significance withthe (CS x MSM)F2 intercross.

References

• Original: J:68402 Suzuki T, et al., Quantitative trait locus analysis of abnormal circadian period in CS mice. Mamm Genome. 2001 Apr;12(4):272-7
• All: 1 reference(s)