Summary |
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Variant origin |
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Variant description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:68402QTLs associated with free running period were provisionally mapped in 289 animals from a (CS x C57BL/6)F2 intercross and confirmed in 192 animals from a (CS x MSM)F2 intercross. Parental strain CS exhibits unstable free running patterns and spontaneous rhythm splitting whereas parental strains C57BL/6 and MSM exhibit regular running patterns. QTLs for long free running period were identified on mouse Chromosome 19 in the (CS x MSM)F2 intercross: Lfp1 maps from 50 cM - tel with a LOD = 4.61 at D19Mit33; Lfp2 maps from 26 cM - 47 cM with a LOD = 4.26 at D19Mit5;and Lfp3 maps from 0 cM - 26 cM with a suggestive LOD = 3.85 at D19Mit32. [See Fig 5.]CS-derived alleles appear to increase the length of the free running period at Lfp1, Lfp2, and Lfp3 in a recessively inherited fashion. No obvious candidate genes were identified at these loci. A suggestive locus mapped to mouse Chromosome 12 from 25 cM - 45 cM with LOD = 3.24 at D12Mit4 in the (CS x C57BL/6)F2 intercross but did not reach statistical significance withthe (CS x MSM)F2 intercross. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/22/2024 MGI 6.24 |
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