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Pas11A/J
QTL Variant Detail
Summary
QTL variant: Pas11A/J
Name: pulmonary adenoma susceptibility 11; A/J
MGI ID: MGI:2446837
QTL: Pas11  Location: Chr10:26890264-26890391 bp  Genetic Position: Chr10, Syntenic
Variant
origin
Strain of Specimen:  A/J
Variant
description
Allele Type:    QTL
Inheritance:    Not Specified
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:48996

Linkage analysis of AXB and BXA RI (recombinant inbred) strains confirmed Pas1 and revealed 3 new loci (Pas11, Pas12, Pas13) modifying pulmonary adenoma susceptibility. Progenitor strain A/J (A) is highly susceptible to both spontaneous and chemically induced lung tumors while progenitor strain C57BL/6J (B) is highly resistant. Analysis of 458 microsatellite markers confirmed Pas1 association (LOD = 5.9 at Kras2) with disease phenotype on mouse chromosome 6 at 72.2 cM. Authors propose Kras (71.2 cM) as the gene for Pas1.

Pas11 maps to mouse chromosome 10 at 21 cM (LOD = 2.4 at D10Mit126). Pas12 (LOD = 2.4 at D17Mit11) maps to 21.95 cM on mouse chromosome 17, and Pas13 (LOD = 2.4 at D19Mit10) maps to 47 cM on mouse chromosome 19. Pas11, Pas12, and Pas13 are believed to be modifiers of Pas1.

References
Original:  J:48996 Lin L, et al., Additional evidence that the K-ras protooncogene is a candidate for the major mouse pulmonary adenoma susceptibility (Pas-1) gene. Exp Lung Res. 1998 Jul-Aug;24(4):481-97
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory