Pas12^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Pas12^C57BL/6J
• Name: pulmonary adenoma susceptibility 12; C57BL/6J
• MGI ID: MGI:2446840
• QTL: Pas12 Location: unknown Genetic Position: Chr17, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:48996

Linkage analysis of AXB and BXA RI (recombinant inbred) strains confirmed Pas1 and revealed 3 new loci (Pas11, Pas12, Pas13) modifying pulmonary adenoma susceptibility. Progenitor strain A/J (A) is highly susceptible to both spontaneous and chemically induced lung tumors while progenitor strain C57BL/6J (B) is highly resistant. Analysis of 458 microsatellite markers confirmed Pas1 association (LOD = 5.9 at Kras2) with disease phenotype on mouse chromosome 6 at 72.2 cM. Authors propose Kras (71.2 cM) as the gene for Pas1.

Pas11 maps to mouse chromosome 10 at 21 cM (LOD = 2.4 at D10Mit126). Pas12 (LOD = 2.4 at D17Mit11) maps to 21.95 cM on mouse chromosome 17, and Pas13 (LOD = 2.4 at D19Mit10) maps to 47 cM on mouse chromosome 19. Pas11, Pas12, and Pas13 are believed to be modifiers of Pas1.

References

• Original: J:48996 Lin L, et al., Additional evidence that the K-ras protooncogene is a candidate for the major mouse pulmonary adenoma susceptibility (Pas-1) gene. Exp Lung Res. 1998 Jul-Aug;24(4):481-97
• All: 1 reference(s)