Bw19^HI
QTL Variant Detail

Summary

• QTL variant: Bw19^HI
• Name: body weight QTL 19; HI
• MGI ID: MGI:2446878
• QTL: Bw19 Location: ChrX:46376920-52412327 bp Genetic Position: ChrX, cM position of peak correlated region/allele: 24.88 cM
• QTL Note: genome coordinates based on the boundaries of the QTL region

Variant origin

• Strain of Specimen: HI

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased early growth rate compared to LI. (J:71307)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Candidate Genes

J:91835

The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A^vy animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A^vy genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes.

On mouse Chromosome X, Atp6ap1 (29.8 cM), Flna (29.8 cM), and Gdi1 (29.8 cM) all show differential expression between A/a and A/A^vy animals on the restricted diet. Diabesity QTLs Bw19 (26.4 cM) and C10bw6 (32 cM) map near these candidate genes. Jarid1c (64 cM) shows differential expression between the restricted and unrestricted diets on the A/A^vy background. Diabesity QTL Dob7 (59.5 cM) maps near Jarid1c.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:45363

Authors localized Bw19, a QTL affecting body weight at 10 weeks, to mouse Chromosome X at approximately 14.1 cM-27.8 cM flanked by DXMit50 and DXMit25. Bw19 was localized by backcrossing (HI x LI)F1 to LI for 6 generations (HI=high body weight inbred line, LI = low body weight inbred line). Overlapping segments of mouse chromosome X from HI donor strain on LI recipient strain background was established in several animals and association between alleles on X chromosome segments and body weight was analyzed. The authors conclude there is a significant association between the proximal end of mouse Chromosome X and body weight at 6 and 10 weeks of age in male and female animals.

References

• Original: J:45363 Rance KA, et al., Mapping quantitative trait loci for body weight on the X chromosome in mice. II. Analysis of congenic backcrosses. Genet Res. 1997 Oct;70(2):125-33
• All: 4 reference(s)